BIOTECHNOLOGY
SPURS GENE THERAPIES THAT TREAT DISEASE

The Gene Therapy Blog describes the use of gene therapies developed through biotechnology in fighting disease.

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OBESITY IS AN EPIDEMIC THAT KILLS 300,000 EACH YEAR

Obesity affects millions of Americans and kills 300,000 each year.

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BIOTECHNOLOGY ENLISTS GENE THERAPY TO FIGHT DISEASE

Biotechnology has created new therapies to treat diseases such as cancer, muscular distrophy, sickle cell anemia, hemophilia, diabetes

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ANTI AGING GENE THERAPY EXTENDS LIFESPAN

Anti Aging Therapy breakthroughs in tissue rejuvenation with stem cells, molecular, repair, gene therapy will enable human to have indefinite lifespans through rejuvenation.

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ALZHEIMERS BREAKTHROUGHS SIGNAL CURE STRATEGIES

Alzheimers breakthroughs highlight the prospect of gene therapies and hormonal therapies and stem cell therapy in the treatment of the disease.

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ADD vs ADHD: A CONTINUUM THAT GAVE ANCIENTS SURVIVAL SKILLS, MODERNS CREATIVITY

ADD vs ADHD: A variant in a DRD4 gene conveyed a selective survival vantage in ancient humans and highly creative intelligence in modern humans.

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AUTISM IS A SPECTRUM OF DISORDERS WITH MANY CAUSES

Unraveling the causes of Autism using genetic, environmental and viral analysis. Mutations of various gene are implicated in different indiviuuals with the disease.

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ALZHEIMERS: THE TOLL OF BETA-AMYLOID AND TAU TANGLES

5.4 million Americans have Alzheimers. One in 8 people over 65. Annual cost $183 billion.

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ADD ADHD: A MODERN DISEASE PUZZLE THAT DEFIES PRECISE DIAGNOSIS

ADD ADHD: Genes or the Environment: It's a wide variety of related disorders whose diagnosis and treatment have been controversial for decades.

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REGENERATIVE MEDICINE: SCIENCE OF REPLACING HEARTS, LIVERS, KIDNEYS, BODY PARTS

Regenerative medicine enables a person’s own cells to grow replacement brain tissue, limb parts, hearts, livers, kidneys with blood supply.

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HEART DISEASE IS A CLASS OF DISEASES THAT INVOLVE BLOOD VESSELS AND ARTERIES

Heart disease is an umbrella term for a variety of diseases affecting the heart. It is the leading cause of death in the United States, Canada, accounting for 25.4% of the total deaths .

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PAIN: CAUSED BY MANY FACTORS: DISEASES, INJURY, NERVOUS SYSTEM DISORDERS

Pain afflicts 20 percent of the American population at any given time. Genetic approaches have indicated its molecular nature.

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WARNING SIGNS DIABETES: THIRST, HUNGER, WEIGHT LOSS

Warning signs diabetes: There are about 16 signs ranging from increased thirst and hunger to frequent urination and weight loss. If you have two or more see your doctor.

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DIABETES MELLITUS - PANCREAS DOES NOT MAKE ENOUGH INSULIN TO METABOLIZE SUGAR.

Diabetes Mellitus strikes when insulin is insufficient for conversion of glucose for internal storage in liver and muscle cells. There are two primary types: 1 and 2.

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STEM CELL RESEARCH DIABETES REVERSES DIABETES BY ADDING PANCREATIC BETA CELLS

Stem cell research diabetes: Research reverses diabetes by replacing pancreatic beta cells in clinical trials.

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STEM CELLS CREATE, REPAIR AND REPLINISH ALL OF THE HUMAN BODY’S ORGANS.

Stem cells are the molecular workhorses of the human body. They can develop into all of the more than 200 cell types of the body.

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NEW GENE LOWERS BODY WEIGHT

Don’t drop those French fries yet! Abraham Kovoor of the University Of Rhode Island College Of Pharmacy discovered a gene that regulates body weight.

Through pure serendipity, he noticed that a protein called RSS9-2 that is related to repetitive movements that are side effects of drugs used to treat Parkinson’s disease and schizophrenia also lowered body weight.

Humans with a gene variation that reduced RGS9-2 levels had a significantly higher body mass index (BMI).

Higher levels of the protein were associated with lower body weight A grossly overweight person has a (BMI), a comparison of weight and height, of over 30 kilograms/meters squared. People with a BMI greater than 40 are morbidly overweight. The condition increases the risk of type 2 diabetes, hypertension, heart disease and cancer.

High levels of the RGS9-2 caused weight loss. The protein is expressed in the brains striatum which is involved in motor control and reward responses and triggers an increased reward response during eating and overeating.

Drop the French fries anyway, they’ll clog your arteries.

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HISTORY OF ADHD: A CONFUSING WORK IN PROGRESS GOING BACK A FEW CENTURIES

History of ADHD goes back at least two centuries when the medical community began to study the characteristics of the disorder. Hyperactivity has long been a part of the human condition.

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3-D PRINTING OF RELACEMENT BODY ORGANS

3-D technology is not only the province of movies like Avatar, It’s being developed to print human body parts and organs.

A CT scan is taken of the your organ and used to prints layers of a replacement organ made up of cells and held together by biomaterials.

Regenerative medicine and human body replacement parts have been the lore of science fiction for generations. You’ve got to have the indelible image of Frankenstein lurking in your brain like a bad Bee Gee tune. Frankenstein was written about 300 years ago, but Modern regenerative medicine is very new.

The Institute of Regenerative medicine at work Forest School of Medicine in North Carolina is working on cell therapies and replacement tissues and organ for 30 difference areas of the body including heart, liver, kidneys and pancreas.

Clinical trials are under way to improve heart function with stem cells and growing organs in the lab like skin, cartilage, bladders, urine tubes, blood vessels and trachea.

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BILLION YEARS OLD ENZYME SLOWS AGING

You will age, we all do. If you're among the majority of the masses you certainly spend a portion of your income on anti-aging remedies. Billions of dollars are spent on such products by Americans. Can aging be slowed?

In 1964 researchers found a drug called rapamycin, which was discovered in a soil sample collected on Easter Island. The drug increased the maximum life span of mammals 10 to 14 percent by interfering with a protein called mTor. Inhibition of mTor mimics calorie restriction long known to slow aging.

mTor, an enzyme encoded by the FRAP1 gene, regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. Slowing the enzyme’s activity can lower the risk of major age-related diseases such as cancer, Alzheimer’s, Parkinson’s, macular degeneration, type 2 diabetes, heart muscle degeneration and osteoporosis.

In 1980 researchers learned that rapamycin inhibited tumor growth.

In 1999 the Food and Drug Administration approved rapamycin to prevent rejection of transplanted organs.

In 2007 two derivatives of rapamycin have been approved to treat various kinds of cancer. The enzyme has the ability to suppress the actions of a growth regulating gene conserved across billions of years of evolution.

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PARKINSONS DISEASE TREATMENT: LEVODOPA, DOPAMINE AGONISTS ARE EFFECTIVE

Parkinsons disease treatment reduces symptoms of tremor, rigidity, Bradykinesia and motion disorders of progressive Parkinsons disease.

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PARKINSONS DISEASE SYMPTOMS REVERSED

Parkinsons Disease Reversed in FDA Phase II Clinical Trial.

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ADENO ASSOCIATED VIRUS IS MULTIFACETED GENE THERAPY TOOL

Adeno associated virus has over 100 tissue specific variants that can be used in multiple gene therapies: Nervous system, brain, eyes, spinal cord.

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CCR5 DELTA 32 MUTATION DEVELOPED INTO TREATMENT THAT CURES OR PREVENTS HIV AIDS

CCR5 Delta mutation developed into gene therapy to Hiv Aids. People with one copy of CCR5 gene are resistant to HIV. Patients with the induced treatment ecame HIV AID resistant.

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HIV AIDS GENE THERAPY POINTS TO CURE

HIV AIDS is a retrovirus that enters body through a protein receptor. The CCR5 gene encodes the receptor. Manipulation of the gene has lead to HIV resistance in individuals.

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OBESITY GENETICS IDENTIFIES CAUSES

Obesity genetics identify many genes causing its onset.

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COMPLICATIONS OF DIABETES CAN DEVELOP BLINDNESS, LIVER, HEART, KIDNEY AND DISEA

Complications of diabetes can lead to diseases of the liver, kidney, cause blindness, heart disease and sexual dysfunction. These conditions can be moderated with tight. glucose control.

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CAUSES OF DIABETES EMBODY A SPECTRUM OF METABOLIC AND AUTOIMMUNE DISORDERS

Causes of diabetes arise from a combination of metabolic and autoimmune disorders having a genetic or lifestyle origin.

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HISTORY OF STEM CELLS: BONE MARROW STEM CELLS USED SUCESSFULLY IN 1956

The history of stem cells began about 340 years ago when Antoine van Leeuweenhoek discovered cells using a crude microscope.

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DEMENTIA AND ALZHEIMERS: DEMENTIA TAKES DIFFERENT FORMS, ALZHEIMERS IS ONE.

Dementia and Alzheimers form a spectrum of diseases that vary in severity from Alzheimers, the most common, to mixed dementia to Creutzfeldt-Jakob disease, the rarest.

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GENE THERAPY - THE DAWN OF THE AGE OF GENETIC MEDICINE

Gene therapy replaces or modifies abnormal, mutated genes with normal genes that treat a spectrum of disease. It's in the vanguard of modern medicine.

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